Expressive

rs10166942 - MSL3B - TRPM8

Magnitude 2.2 · 6 studies on file

Reported associations

  • Genome-wide Association Study Reveals Three Susceptibility Loci for Common Migraine in the General Population - Unknown journal (n.d.) · Unknown authors · PubMed 21666692

    ABSTRACT: In a population-based genome-wide analysis including 5122 migraineurs and 18,108 non-migraineurs, rs2651899 (PRDM16), rs10166942 (TRMP8), and rs11172113 (LRP1) were among the top associations (p<5×10−6) with migraine. All three SNPs were significant in meta-analysis among replication cohorts and met genome-wide significance (p<4.3×10−9) in meta-analysis combining discovery and replication cohorts. Rs2651899 and rs10166942 associated with migraine compared to non-migraine headache; none of the three SNPs specifically associated with migraine subtypes or features. FULL TEXT: [INTRO] Migraine is a common and often debilitating disorder affecting up to 20% of the population, women 3-4 times more often than men. Clinically, migraine manifests with recurrent attacks of headach

  • Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine - Unknown journal (n.d.) · Unknown authors · PubMed 27322543

    ABSTRACT: Migraine is a debilitating neurological disorder affecting around 1 in 7 people worldwide, but its molecular mechanisms remain poorly understood. Some debate exists over whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we performed the largest genetic study of migraine to date, comprising 59,674 cases and 316,078 controls from 22 GWA studies. We identified 44 independent single nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10−8) that map to 38 distinct genomic loci, including 28 loci not previously reported and the first l

  • Genome-wide association analysis identifies susceptibility loci for migraine without aura - Unknown journal (n.d.) · Unknown authors · PubMed 22683712

    ABSTRACT: Migraine without aura is the most common form of migraine, characterized by recurrent disabling headache and associated autonomic symptoms. To identify common genetic variants for this migraine type, we analyzed genome-wide association data of 2,326 clinic-based German and Dutch patients and 4,580 population-matched controls. We selected SNPs from 12 loci with two or more SNPs with P-values < 1 × 10−5 for follow-up in 2,508 patients and 2,652 controls. Two loci, i.e. 1q22 (MEF2D) and 3p24 (near TGFBR2) replicated convincingly (P = 4.9 × 10−4, P = 1.0 × 10−4, respectively). Meta-analysis of the discovery and replication data yielded two additional genome-wide significant (P < 5 × 10−8) loci in PHACTR1 and ASTN2. In addition, SNPs in two previously reported migraine loc

  • Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles - Unknown journal (n.d.) · Unknown authors · PubMed 35115687

    ABSTRACT: Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are previously unknown. These loci provide an opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes: migraine with aura and migraine without aura. Stratification of the risk loci using 29,679 cases with subtype information indicated three risk variants that seem specific for migraine with aura (in HMOX2, CACNA1A and MPPED2), two that seem specific for migraine without aura (near SPINK2 and near FECH) and nine that increase susceptibility for migraine regardless of subtype. The new risk loci include

  • New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 34294844

    ABSTRACT: Migraine is a common disabling primary headache disorder that is ranked as the most common neurological cause of disability worldwide. Women present with migraine much more frequently than men, but the reasons for this difference are unknown. Migraine heritability is estimated to up to 57%, yet much of the genetic risk remains unaccounted for, especially in non-European ancestry populations. To elucidate the etiology of this common disorder, we conduct a multiethnic genome-wide association meta-analysis of migraine, combining results from the GERA and UK Biobank cohorts, followed by a European-ancestry meta-analysis using public summary statistics. We report 79 loci associated with migraine, of which 45 were novel. Sex-stratified analyses identify three additional novel loci (CPS

  • Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits - Unknown journal (n.d.) · Unknown authors · PubMed 37844115

    ABSTRACT: Chronic pain is at epidemic proportions in the United States, represents a significant burden on our public health system, and is coincident with a growing opioid crisis. While numerous genome-wide association studies have been reported for specific pain-related traits, many of these studies were underpowered, and the genetic relationship among these traits remains poorly understood. Here, we conducted a joint analysis of genome-wide association study summary statistics from seventeen pain susceptibility traits in the UK Biobank. This analysis revealed 99 genome-wide significant risk loci, 65 of which overlap loci identified in earlier studies. The remaining 34 loci are novel. We applied leave-one-trait-out meta-analyses to evaluate the influence of each trait on the joint analys

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