rs1008463 - SH3PXD2A: CD8A link
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- This variant is linked to higher CD8A levels in a small study.
- It may affect expression in skin and esophagus tissue.
- The evidence comes from a GWAS catalog association.
Key takeaways This variant is linked to higher CD8A levels in a small study. It may affect expression in skin and esophagus tissue. The evidence comes from a GWAS catalog association.
What the research says This variant is associated with higher CD8A levels in individuals studied [PMID 38326779]. The association was observed across a sample of about 318 participants [PMID 38326779].
Reported associations CD8A: the variant is linked to higher protein levels with a reported effect size of 4.53 p=6e-6 in about 318 individuals [PMID 38326779].
Evidence quality The GWAS catalog association is based on a single study of 318 participants with a small effect size and highly significant p-value; no other studies are provided so the evidence cannot be considered replicated [PMID 38326779].
Tissue- specific expression effects
- SH3PXD2A: the variant is linked to increased expression in skin sun exposed lower leg GTEx Portal.
- STN1: the variant is linked to increased expression in esophagus mucosa GTEx Portal.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does the SH3PXD2A gene do?
The SH3PXD2A gene encodes a protein that can influence how cells respond to signals.
Is rs1008463 linked to osteoporosis?
No evidence links this variant to bone health.
Can I get my DNA analyzed for this variant?
Yes you can upload your raw 23andMe file and we will interpret it.