rs10033119 - NPY1R

Magnitude 4.5 · 2 studies on file

Reported associations

• Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population. - Journal of lipid research (2019) · Hebbar P, Nizam R, Melhem M, Alkayal F, Elkum N, John SE, Tuomilehto J, Alsmadi O, Thanaraj TA · PubMed 30108155

  Abnormal blood lipid levels are influenced by genetic and lifestyle/dietary factors. Although many genetic variants associated with blood lipid traits have been identified in Europeans, similar data in Middle Eastern populations are limited. We performed a genome-wide association study with Arab individuals (discovery cohort: 1,353; replication cohort: 1,176) from Kuwait to identify possible associations of genetic variants with high lipid levels. We used Illumina HumanOmniExpress BeadChip and candidate SNP genotyping in the discovery and replication phases, respectively. For association tests, we used genetic models that were based on additive and recessive modes of inheritance. High triglycerides (TGs) were recessively associated with six risk variants (rs1002487/ , rs11805972/ ) rs77617

• Genome wide association study identifies two loci associated with cadmium in erythrocytes among never-smokers. - Human molecular genetics (2017) · Borné Y, Söderholm M, Barregard L, Fagerberg B, Persson M, Melander O, Thévenod F, Hedblad B, Engström G · PubMed 27005419

  Cadmium is a non-essential toxic metal with multiple adverse health effects. Exposure in the general population occurs by smoking and diet. Cadmium in erythrocytes is a valid biomarker of exposure and body burden of cadmium. We aimed to identify genetic variants related to concentrations of cadmium in erythrocytes. Erythrocyte cadmium was analyzed in 4432 individuals (1728 never smokers) from the Swedish population-based Malmö Diet and Cancer cohort. Genotyping was performed using the Illumina HumanOmniExpressExome Bead chip with genome-wide coverage. Genome wide analyses were performed in the whole sample and in never smokers. No single nucleotide polymorphism (SNP) reached a genome-wide significant association with erythrocyte cadmium in the whole sample. However, in never smokers, 14 v

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