Expressive

rs1002487 - RPS6KA1

Magnitude 4.5 · 2 studies on file

Reported associations

  • Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population. - Journal of lipid research (2019) · Hebbar P, Nizam R, Melhem M, Alkayal F, Elkum N, John SE, Tuomilehto J, Alsmadi O, Thanaraj TA · PubMed 30108155

    Abnormal blood lipid levels are influenced by genetic and lifestyle/dietary factors. Although many genetic variants associated with blood lipid traits have been identified in Europeans, similar data in Middle Eastern populations are limited. We performed a genome-wide association study with Arab individuals (discovery cohort: 1,353; replication cohort: 1,176) from Kuwait to identify possible associations of genetic variants with high lipid levels. We used Illumina HumanOmniExpress BeadChip and candidate SNP genotyping in the discovery and replication phases, respectively. For association tests, we used genetic models that were based on additive and recessive modes of inheritance. High triglycerides (TGs) were recessively associated with six risk variants (rs1002487/ , rs11805972/ ) rs77617

  • Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population - Unknown journal (n.d.) · Unknown authors · PubMed 31932636

    ABSTRACT: Consanguineous populations of the Arabian Peninsula, which has seen an uncontrolled rise in type 2 diabetes incidence, are underrepresented in global studies on diabetes genetics. We performed a genome-wide association study on the quantitative trait of fasting plasma glucose (FPG) in unrelated Arab individuals from Kuwait (discovery-cohort:n = 1,353; replication-cohort:n = 1,196). Genome-wide genotyping in discovery phase was performed for 632,375 markers from Illumina HumanOmniExpress Beadchip; and top-associating markers were replicated using candidate genotyping. Genetic models based on additive and recessive transmission modes were used in statistical tests for associations in discovery phase, replication phase, and meta-analysis that combines data from both the phas

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • fasting glucose and HbA1c High

    RPS6KA1 rs1002487 risk allele is strongly associated with elevated fasting plasma glucose and glycated hemoglobin, markers of impaired glucose homeostasis and type 2 diabetes risk.

    HbA1c and fasting glucose testing annually; more frequently if results are elevated or in prediabetic range

  • triglyceride levels High

    RPS6KA1 rs1002487 risk allele is strongly associated with elevated triglycerides, a dyslipidemia marker linked to metabolic syndrome and cardiovascular disease risk.

    Lipid panel including triglycerides annually; more frequently if elevated

Discuss with your doctor

  • metabolic risk and type 2 diabetes prevention High

    Combined genetic risk for elevated glucose and triglycerides significantly increases type 2 diabetes and metabolic syndrome risk.