rs1002957030 - LINC02763 - NCAM1-AS2

Magnitude 2.2 · 1 study on file

Reported associations

• The genome-wide association study of serum IgE levels demonstrated a shared genetic background in allergic diseases. - Clinical immunology (Orlando, Fla.) (2024) · Lu HF, Chou CH, Lin YJ, Uchiyama S, Terao C, Wang YW, Yang JS, Liu TY, Wong HS, Chen SC, Tsai FJ · PubMed 38199299

  Immunoglobulin E (IgE) synthessis is highly related to a variety of atopic diseases, and several genome-wide association studies (GWASs) have demonstrated the association between genes and IgE level. In this study, we conducted the largest genome-wide association study of IgE involving a Taiwanese Han population. Eight independent variants exhibited genome-wide significance. Among them, an intronic SNP of CD28, rs1181388, and an intergenic SNP, rs1002957030, on 11q23.2 were identified as novel signals for IgE. Seven of the loci were replicated successfully in a meta-analysis using data on Japanese population. Among all the human leukocyte antigen (HLA) regions, HLA-DQA103:02 - HLA-DQB103:03 was the most significant haplotype (OR = 1.25, SE = 0.02, FDR = 1.6 × 10 ), corresponding

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