rs10009842 (LINC03140-JADRR): Height Association

Key takeaways

• Identified as one of 12,111 common variants significantly linked to adult height in a genome-wide association study of more than 5.4 million people from diverse ancestries.
• Located in the LINC03140 - JADRR genomic region; LINC03140 is a long intergenic non-coding RNA gene (a gene that produces an RNA molecule rather than a protein).
• Together, all 12,111 height-associated variants from that study collectively explain roughly 40% of height differences among people of European ancestry.
• Effect size patterns were broadly similar across ancestry groups, though genetic prediction accuracy was lower in non-European populations.
• No lifestyle, drug response, or tissue expression findings are currently on file for this specific variant.

What the research says rs10009842, in the LINC03140 - JADRR region, was identified among 12,111 independent common SNPs (single-nucleotide polymorphisms - single-letter changes in the DNA sequence) that reached genome-wide significance for association with adult height in a meta-analysis spanning 5.4 million individuals from multiple ancestry groups, the largest height genetics study reported to date. These 12,111 SNPs cluster within 7,209 non-overlapping genomic segments averaging roughly 90 kilobases each and collectively span about 21% of the human genome, together accounting for nearly all of the height heritability attributable to common genetic variants. In out-of-sample prediction testing, this full catalog of variants explained roughly 40% of height variance in people of European ancestry and 10-20% in other ancestry groups, with lower prediction accuracy in non-European groups attributed to differences in linkage disequilibrium (the tendency of nearby variants to be inherited together) and allele frequencies.

Reported associations

• Adult human height: rs10009842 is listed among 12,111 SNPs significantly associated with adult stature in a genome-wide meta-analysis of 5,380,080 individuals from 281 studies; the individual effect size for this specific variant is not reported in the available study text.

Evidence quality The association derives from one of the largest genetic studies of any human trait to date, covering 5,380,080 participants from 281 studies. The sample was predominantly of European ancestry (approximately 76%), with East Asian (approximately 9%), Hispanic admixed (approximately 8.5%), African (approximately 5.5%), and South Asian (approximately 1.4%) participants also included. The 12,111 height-associated SNPs, which include rs10009842, met genome-wide significance thresholds - a statistical bar used to control for testing millions of variants simultaneously. The authors describe this map as effectively saturated for common variation in European-ancestry populations, meaning additional common variants with detectable effects on height are unlikely to be found in that group with current approaches. An individual-level p-value and effect size for rs10009842 are not available in the provided study text, limiting variant-specific interpretation. Only one study was supplied, so no conflicting findings exist to report.

Lifestyle considerations No lifestyle considerations on file for this variant.