TMEM132D, variants, traits, and what the research shows

TMEM132D - what this gene does

Variants catalogued in TMEM132D (transmembrane protein 132D) span four broad trait themes - metabolic, cardiovascular, cancer, and respiratory - placing this gene at the intersection of several active areas of genome-wide association study (GWAS - a study that scans many people's genomes for variants statistically associated with a trait) research. The published variant summary for the highest-ranked entry on file contained no extractable detail, so this entry characterises the gene through the trait patterns its variant data reveals rather than molecular mechanism.

Key takeaways

• Five of this gene's highest-ranked variants span all four trait categories: metabolic, cardiovascular, cancer, and respiratory.
• Two separate top-tier variants are independently linked to cardiovascular traits - the strongest internal replication signal in the dataset.
• One top-tier variant each is linked to a metabolic trait, a cancer trait, and a respiratory trait.
• 134 variants are catalogued in total; most lack detailed trait annotations and remain under-characterised.
• All associations listed here are population-level statistical signals, not predictors of any individual's health outcome.

Notable variants

The five highest-magnitude variants each score 4.50, the top score on file for this gene. rs114606502 is linked to a metabolic trait. rs12824981 and rs945946962 are each independently associated with cardiovascular traits - two distinct variants pointing to the same broad category, representing the strongest within-gene replication signal in this dataset. rs4759570 is linked to a cancer trait, and rs79946301 to a respiratory trait. A cluster of magnitude-3.00 variants - including rs1025938059, rs1026943926, rs116456206, rs1242467133, and rs1244480082 among others - carry no published trait annotations and await further characterisation.

Trait associations

The variant data points to four trait domains:

• Metabolic: rs114606502 (magnitude 4.50) is associated with a metabolic trait.
• Cardiovascular: Both rs12824981 and rs945946962 (each magnitude 4.50) are independently linked to cardiovascular traits. Two distinct high-magnitude variants converging on the same trait category provides modest internal replication within this dataset.
• Cancer: rs4759570 (magnitude 4.50) is linked to a cancer trait.
• Respiratory: rs79946301 (magnitude 4.50) is associated with a respiratory trait.

Evidence quality

All five top-tier variants share a magnitude score of 4.50, the highest recorded for this gene. The cardiovascular category is the most internally replicated signal, appearing across two independent top-tier variants (rs12824981 and rs945946962). Of the 21 variants flagged as having prior research summaries, only one published editorial was retrievable at page-generation time and it contained no extractable effect sizes, odds ratios, sample sizes, or multi-cohort replication data. The remaining majority of the 134 catalogued variants, predominantly at magnitude 3.00, carry no trait annotations; their biological or clinical significance is currently unknown. All associations should be treated as preliminary GWAS-level signals pending broader characterisation and independent replication.

What this is NOT

These variants are population-level statistical associations drawn from genome-wide studies; they describe patterns observed across large groups of people and are not deterministic predictors of any individual's health or disease risk. Nothing in this entry constitutes medical advice, a diagnosis, or a recommendation to take any action.