Expressive

rs114606502 - TMEM132D

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome-wide association analysis of metabolic syndrome quantitative traits in the GENNID multiethnic family study - Unknown journal (n.d.) · Unknown authors · PubMed 34074324

    ABSTRACT: Background To identify genetic associations of quantitative metabolic syndrome (MetS) traits and characterize heterogeneity across ethnic groups. Methods Data was collected from GENetics of Noninsulin dependent Diabetes Mellitus (GENNID), a multiethnic resource of Type 2 diabetic families and included 1520 subjects in 259 African-American, European-American, Japanese-Americans, and Mexican-American families. We focused on eight MetS traits: weight, waist circumference, systolic and diastolic blood pressure, high-density lipoprotein, triglycerides, fasting glucose, and insulin. Using genotyped and imputed data from Illumina's Multiethnic array, we conducted genome-wide association analyses with linear mixed models for all ethnicities, except for the smaller Japanese-American gro

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • reduce refined carbohydrates and added sugars Moderate

    refined carbohydrates and added sugars increase fasting triglycerides, especially in carriers of triglyceride-raising variants

    limit added sugars to <10% of daily calories; replace refined grains with whole grains

Discuss with your doctor

  • triglyceride management strategy Moderate

    rs114606502 is associated with elevated triglycerides, a modifiable cardiovascular risk factor

    discuss at routine visit or if triglycerides >150 mg/dL

Exercise

  • aerobic exercise Moderate

    aerobic exercise reduces fasting triglyceride levels

    150 minutes of moderate-intensity aerobic exercise per week

Screening

  • annual lipid panel with triglyceride measurement Moderate

    rs114606502 associated with elevated fasting triglyceride levels in African Americans

    annual fasting lipid panel; screen more frequently if triglycerides >150 mg/dL