TESHL, variants, traits, and what the research shows

TESHL - what this gene does

TESHL is a human gene whose variant set, as currently documented, clusters around two trait themes: liver-related traits and cancer. The molecular function of this gene is not characterized here - the content below is grounded solely in the variant associations on file.

Key takeaways

• Variants in this gene are associated with both liver-related traits and cancer across multiple independent entries in the dataset.
• The highest-magnitude variants on file reach a score of 4.50, with both liver and cancer trait labels represented at that tier.
• Four separate moderate-magnitude variants each independently carry a cancer trait association, suggesting a recurring directional signal within this gene.
• These are population-level statistical associations and do not predict individual health outcomes.
• Full evidence details - including sample sizes and cohort replication - are pending for most listed variants.

Notable variants

Among the highest-magnitude variants (4.50), rs10179787 carries a liver trait association and rs59213897 carries a cancer trait association. Several other magnitude-4.50 variants - rs1014680, rs10203066, rs115726381, rs12623304, rs17835044, rs185289343, rs35463043, and rs6755489 - are on file without published trait detail in the current dataset. At moderate magnitude (2.80), rs10209782 is linked to liver traits, while rs12998806, rs2372943, rs34005590, and rs72951831 are each independently associated with cancer traits.

Trait associations

The two dominant trait themes across this gene's variant set are liver-related traits and cancer. Liver associations appear at the highest magnitude tier via rs10179787 and at the moderate tier via rs10209782. Cancer associations span a broader range of variants: rs59213897 at magnitude 4.50, and rs12998806, rs2372943, rs34005590, and rs72951831 at magnitude 2.80. The recurrence of cancer-linked signals across four separate moderate-magnitude variants is a meaningful directional pattern, though independent replication across additional cohorts is required before any causal inference can be drawn.

Evidence quality

This gene's dataset contains 148 total variants, 23 of which carry prior research summaries, and a subset of which carry explicit trait labels (liver or cancer). The magnitude scores reflect a composite of effect size and evidence strength, with the highest entries at 4.50. However, the editorial summaries for all currently listed variants are unpopulated, which prevents granular review of sample sizes, cohort composition, or replication status for individual entries. Most findings are consistent with GWAS (genome-wide association study - a method that scans large populations for genetic variants statistically linked to a trait) signals, which describe population-level correlations rather than established molecular mechanisms. The clustering of cancer-associated variants across four independent entries at magnitude 2.80 is the strongest directional signal in this dataset, but should be treated as preliminary until independently replicated with full effect-size reporting.

What this is NOT

These variants represent population-level statistical signals, not deterministic predictors of any trait or condition for any individual. This page does not constitute medical advice, a diagnosis, or a recommendation for any action.