Expressive

rs10203066 - TESHL

Magnitude 4.5 · 1 study on file

Reported associations

  • Shared genetic susceptibility between trigger finger and carpal tunnel syndrome: a genome-wide association study - Unknown journal (n.d.) · Unknown authors · PubMed 36043126

    ABSTRACT: Summary Background Trigger finger and carpal tunnel syndrome are the two most common non-traumatic connective tissue disorders of the hand. Both of these conditions frequently co-occur, often in patients with rheumatoid arthritis. However, this phenotypic association is poorly understood. Hypothesising that the co-occurrence of trigger finger and carpal tunnel syndrome might be explained by shared germline predisposition, we aimed to identify a specific genetic locus associated with both diseases. Methods In this genome-wide association study (GWAS), we identified 2908 patients with trigger finger and 436 579 controls from the UK Biobank prospective cohort. We conducted a case-control GWAS for trigger finger, followed by co-localisation analyses with carpal tunnel syndrome summ

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • fasting IGF-1 plasma concentration Moderate

    Elevated plasma IGF-1 is independently associated with increased trigger finger and carpal tunnel syndrome risk; variant effect is mediated through IGF-1 antagonism pathway.

    Baseline measurement if symptoms present or at healthcare provider recommendation

Discuss with your doctor

  • genetic risk stratification and early intervention strategies for trigger finger High

    Variant confers 7.6-fold increased genetic susceptibility to trigger finger via DIRC3-IGFBP5 axis; mechanistic understanding enables targeted prevention discussion.

Screening

  • trigger finger and carpal tunnel syndrome clinical evaluation High

    Genetic variant at DIRC3 locus confers significantly increased risk of trigger finger through altered IGFBP5-mediated IGF-1 signaling, warranting structured surveillance.

    Annual hand/wrist clinical examination; seek evaluation if finger clicking, locking, or paresthesia develops