TCF7L2, variants, traits, and what the research shows
The TCF7L2 gene is associated with rare disease and mental health conditions via common variants.
- High-magnitude variants on file
- 217
- With published research summary
- 47
- Trait themes
- 5
TCF7L2 - what this gene does
TCF7L2 is a transcription factor that influences pathways related to rare disease, mental health, cardiovascular, and metabolic traits. rs10885418 rs12251238 rs10128255 rs12265291 rs10885414
Key takeaways
- This gene is linked to rare disease and mental health conditions.
- Variants such as rs10885418 and rs12251238 are associated with these traits.
- The evidence comes from published GWAS studies.
Notable variants The highest-magnitude variants include rs10885418, rs12251238, rs10128255, rs12265291, and rs10885414. Each has a magnitude of 2.20 and appears in published pages rs####.
Trait associations These variants are associated with rare disease and mental health traits. Replication across multiple studies strengthens the signal.
Evidence quality The evidence is based on GWAS findings from large sample sizes, but most results are population-level signals not individual predictions. The effect sizes are moderate and some findings are single-cohort.
What this is NOT These variants are statistical associations in populations, not deterministic health outcomes for any person. We do not prescribe or diagnose.
Traits this gene affects
- rare_disease
- mental_health
- cardiovascular
- metabolic
Top variants in TCF7L2
Highest-impact rsids on file, sorted by magnitude. Linked entries have a full research summary; unlinked entries are in the catalog but not yet written up.
| rsid | Magnitude | Primary trait |
|---|---|---|
| rs2136838531 | 5.5 | rare_disease |
| rs2137155220 | 5.5 | mental_health |
| rs2137178349 | 5.5 | rare_disease |
| rs2137179429 | 5.5 | rare_disease |
| rs2544045443 | 5.5 | rare_disease |
| rs2136929776 | 5.0 | rare_disease |
| rs2137178800 | 5.0 | rare_disease |
| rs182893628 | 4.5 | cardiovascular |
| rs386418874 | 4.5 | metabolic |
| rs72826094 | 4.5 | |
| rs1018211508 | 3.0 | rare_disease |
| rs1023635345 | 3.0 | rare_disease |
| rs1036930478 | 3.0 | rare_disease |
| rs1174743549 | 3.0 | rare_disease |
| rs1207216340 | 3.0 | rare_disease |
| rs1390561716 | 3.0 | rare_disease |
| rs1396649788 | 3.0 | metabolic |
| rs1447890173 | 3.0 | rare_disease |
| rs1468304465 | 3.0 | rare_disease |
| rs185631836 | 3.0 | rare_disease |