SPRY4-AS1, variants, traits, and what the research shows

SPRY4-AS1 - what this gene does

SPRY4-AS1 is a gene whose catalogued variants appear across genome-wide association studies (GWAS - population-scale scans that identify genetic variants statistically linked to a trait) spanning a notably wide range of domains: vision, cardiovascular health, cancer, kidney function, musculoskeletal traits, neurological traits, metabolic measures, liver health, and sleep.

Key takeaways

• Two independent high-magnitude variants link this gene to vision traits.
• A high-magnitude variant is associated with cancer risk.
• Cardiovascular, metabolic, and musculoskeletal associations each appear across multiple independent variants.
• Kidney, neurological, liver, and sleep traits also have associated variants in this gene.
• All findings are population-level statistical associations, not deterministic predictors for any individual.

Notable variants

The top-tier signals (magnitude 4.50) span several domains: rs152446 and rs249767 are both linked to vision traits, making vision the only trait with two independent variants at this level. rs17577085 is associated with cardiovascular traits at the same tier. rs77073849 carries a cancer association, also at magnitude 4.50. rs115489684 and rs574177860 round out the top-tier set. Stepping down to magnitude 2.80, rs59983575 is the sole mid-tier variant, linked to kidney-related traits, before a broader cluster of 2.20-magnitude variants.

Trait associations

Vision: Two of the six highest-magnitude variants - rs152446 and rs249767 - are linked to vision traits. Their co-presence at the top tier may indicate a comparatively consistent signal for this domain.

Cardiovascular: The cardiovascular association appears at two distinct magnitude levels: rs17577085 at 4.50, and rs10477176 and rs10515514 at the 2.20 level - three variants spanning the range.

Metabolic: Three variants at the 2.20 level - rs10477191, rs112907088, and rs11325555 - are flagged for metabolic traits, making this one of the more multiply-represented themes in the lower tier.

Musculoskeletal: rs10038860, rs10062749, and rs10076308 are all associated with musculoskeletal traits at the 2.20 level.

Other domains: Single variants associate with cancer (rs77073849), kidney (rs59983575), neurological (rs10066796), liver (rs10077941), and sleep (rs10477173) traits.

Evidence quality

The strongest signals on file reach magnitude 4.50 across six variants, with vision being the only trait represented by two independent variants at that level - a modest internal replication signal within this dataset. Cardiovascular, metabolic, and musculoskeletal traits each appear across multiple lower-magnitude variants, adding breadth of representation. However, the individual SNP summaries currently available for this gene do not include effect sizes, odds ratios, or cohort sample sizes, so the precise strength and direction of each association cannot be characterised here. Of 89 total variants on file, 22 carry prior research summaries, meaning the evidence base is still developing; all findings should be treated as preliminary signals requiring further characterisation.

What this is NOT

All variants described here are population-level statistical associations from GWAS research - they reflect patterns across large groups and are not deterministic predictors of any individual's health outcomes or traits. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.