rs10477176 - SPRY4-AS1
Magnitude 2.2 · 1 study on file
Reported associations
-
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 30578418
ABSTRACT: In this trans-ethnic multi-omic study we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenome, and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in GWASs of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically-predicted gene expression of 840 genes in 45 tissues, and murine renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells. Editorial summary: Analysis of blood pressure data from
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
-
DASH diet for systolic BP reduction Moderate
Genetic risk for hypertension warrants evidence-based dietary BP management
Follow DASH pattern; limit sodium to <2.3g/day, increase fruits and vegetables
Exercise
-
Aerobic exercise for BP control Moderate
Genetic predisposition to elevated systolic BP indicates benefit from exercise-based BP reduction
150 minutes per week moderate-intensity aerobic exercise
Screening
-
Blood pressure screening for genetic risk Moderate
Variant associated with 0.184 SD increase in systolic BP across 459,777 individuals
Annual BP check starting age 30; more frequently if elevated