SGO1-AS1, variants, traits, and what the research shows

SGO1-AS1 - what this gene does

SGO1-AS1 is a human gene with variants linked in genetic research to a range of traits including kidney function, neurological conditions, cardiovascular health, cancer, and mental health. The variants on file do not yet carry detailed mechanistic summaries, so what follows reflects the trait signals observed in the available data.

Key takeaways

• Four separate variants in this gene carry cancer-related associations, making cancer the most represented trait category
• Kidney, neurological, and cardiovascular traits each have at least one linked variant among the top signals
• A mental health association exists at a lower evidence magnitude than the leading signals
• The strongest variants all share the same top evidence score, but detailed effect sizes are not yet available
• These are population-level statistical signals from genetic studies, not predictors for any individual

Notable variants

Among the highest-magnitude signals (all scoring 4.50), rs11720887 is linked to kidney traits, rs117975786 to neurological conditions, and rs139992073 to cardiovascular traits. Four variants share a cancer association at the same magnitude: rs184639265, rs73188336, rs77589217, and rs79727293. Additional top-magnitude signals include rs74696548 tied to immune traits and rs79019300 tied to liver-related traits. The variant rs1395103 appears at a lower magnitude of 2.80, linked to mental health traits.

Trait associations

Cancer is the most replicated trait category in this gene, represented by four distinct variants, rs184639265, rs73188336, rs77589217, and rs79727293, which strengthens the overall signal relative to single-variant findings. Kidney function appears through rs11720887, neurological conditions through rs117975786, and cardiovascular traits through rs139992073. Immune and liver-related traits are each represented by a single variant (rs74696548 and rs79019300 respectively). Mental health is linked through rs1395103, though at a lower evidence score than the other trait categories.

Evidence quality

The leading variants all carry an evidence magnitude of 4.50, the highest score in this dataset. Four of those, including rs11718323, rs117975786, rs11720887, and rs115234822, have published editorial pages indicating more developed documentation. Effect sizes (such as odds ratios or beta coefficients, numbers that quantify how strongly a variant shifts a measured trait value or risk estimate) and sample sizes are not on file for any variant here, which limits confidence in the magnitude of these associations. The mental health signal via rs1395103 scores at 2.80, the lowest in this set, suggesting a weaker or less-replicated finding. All associations should be treated as preliminary leads from GWAS (genome-wide association studies, a method that scans large groups of people's genomes for statistical links to traits) rather than established causal relationships.

What this is NOT

These variants are population-level statistical signals and do not predict any outcome for a specific person. This content does not constitute medical advice, a diagnosis, or a treatment recommendation of any kind.