Expressive

rs11720887 - SGO1-AS1

Magnitude 4.5 · 1 study on file

Reported associations

  • Genetic loci associated with renal function measures and chronic kidney disease in children: the Pediatric Investigation for Genetic Factors Linked with Renal Progression Consortium. - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2016) · Wuttke M, Wong CS, Wühl E, Epting D, Luo L, Hoppmann A, Doyon A, Li Y, Sözeri B, Thurn D, Helmstädter M, Huber TB, Blydt-Hansen TD, Kramer-Zucker A, Mehls O, Melk A, Querfeld U, Furth SL, Warady BA, Schaefer F, Köttgen A · PubMed 26420894

    Chronic kidney disease (CKD) in children is characterized by rapid progression and a high incidence of end-stage renal disease and therefore constitutes an important health problem. While unbiased genetic screens have identified common risk variants influencing renal function and CKD in adults, the presence and identity of such variants in pediatric CKD are unknown. The international Pediatric Investigation for Genetic Factors Linked with Renal Progression (PediGFR) Consortium comprises three pediatric CKD cohorts: Chronic Kidney Disease in Children (CKiD), Effect of Strict Blood Pressure Control and ACE Inhibition on the Progression of CRF in Pediatric Patients (ESCAPE) and Cardiovascular Comorbidity in Children with CKD (4C). Clean genotype data from > 10 million genotyped or imputed sin

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • serum creatinine and estimated glomerular filtration rate Moderate

    Tracks kidney function decline and early CKD stages in individuals with elevated genetic risk.

    annual testing starting at age 30 or per clinician recommendation

Discuss with your doctor

  • genetic CKD risk and kidney-protective strategy Moderate

    Genetic predisposition to proteinuria requires professional assessment for personalized monitoring and prevention.

Screening

  • kidney function and proteinuria status Moderate

    rs11720887-A is associated with increased risk of proteinuria and chronic kidney disease; early detection enables preventive intervention.

    baseline serum creatinine, eGFR, and urinalysis; repeat annually or per clinician guidance