ROBO1, variants, traits, and what the research shows

ROBO1 - what this gene does

ROBO1 is a human gene with variants across three broad trait themes visible in the current catalog: rare disease categories, kidney-related conditions, and hormonal traits. No detailed mechanism or function data is available from the variant summaries on file; the sections below describe only what the cataloged variants reveal.

Key takeaways

• ROBO1 variants are linked to rare disease, kidney, and hormonal trait categories.
• 14 of the top 20 highest-magnitude variants are flagged for rare disease categories.
• 5 top-magnitude variants are associated with kidney-related trait categories.
• All 20 top-listed variants share a consistent magnitude score of 5.50.
• The full ROBO1 catalog holds 330 variants spanning multiple trait areas.

Notable variants

All 20 highest-magnitude variants on file carry a score of 5.50. Among those in the rare disease category are rs1181501831, rs148625921, rs199577218, rs199958211, and rs34515208. Kidney-category signals include rs1705825244, rs1706269517, rs2081036277, rs2107620759, and rs377297596. A hormonal trait category variant appears at rs2081940708. Specific trait names and effect sizes are not yet on file for these rsids.

Trait associations

Three trait themes emerge from the variant catalog. Rare disease associations account for the largest share of top-magnitude variants, with 14 of 20 carrying that label, including rs1181501831, rs148625921, rs189089312, rs199577218, rs199958211, rs2107823148, rs2471718612, rs2472352059, rs2545634068, rs34515208, rs367940062, rs371765552, rs538506408, and rs545722249. Kidney-related trait variants include rs1705825244, rs1706269517, rs2081036277, rs2107620759, and rs377297596. A single hormonal trait variant, rs2081940708, completes the top-20 catalog at this magnitude level.

Evidence quality

No study-level metadata (such as sample sizes, odds ratios, or replication status) is currently on file for these variants. All 20 listed variants share a magnitude score of 5.50, indicating consistent weighting within the internal catalog, but this score alone does not confirm replication or large-cohort validation. The full catalog for this gene contains 330 variants, so the 20 listed here represent only the top tier by magnitude; the remaining variants may carry different trait themes or evidence profiles. These entries should be read as flags pointing to areas of research interest, not as confirmed, peer-reviewed associations.

What this is NOT

These variants are population-level statistical signals from genome-wide association studies (GWAS - studies that scan large groups of people for genetic variants statistically linked to a trait) and are not deterministic predictors of any health outcome for any individual. This page does not prescribe, diagnose, or advise any course of action.