PRKG1, variants, traits, and what the research shows

PRKG1 - what this gene does

Based on the variants catalogued here, PRKG1 (located at chromosome 10q11) shows up consistently in research linked to cardiovascular traits - making it a gene of notable interest in heart and blood vessel health research.

Key takeaways

• PRKG1 has over 400 variants on file, with 19 reaching the highest magnitude score in this dataset, all linked to cardiovascular traits.
• When many independent variants within a single gene all point toward the same trait domain, that convergence is generally viewed as a more robust signal than any single isolated hit.
• One variant, rs10824002, carries a lower magnitude score and has no trait label yet assigned.
• Detailed per-variant data - such as odds ratios, cohort sizes, and replication status - is not yet available in the summaries for this gene.
• These are population-level statistical associations, not personal health predictions.

Notable variants

Nineteen variants share the highest magnitude score in this dataset (5.50), all flagged for cardiovascular trait associations. Among the strongest signals are rs140716870, rs142375882, rs146504019, rs146785168, and rs200818051. Further high-magnitude variants in the same tier include rs374166820, rs374445349, rs376134488, rs397515330, rs74905373, rs761759814, rs767330363, rs770812712, rs774710312, rs775372704, rs776048746, rs886039042, rs886039153, and rs985916344. One additional variant, rs10824002, sits at magnitude 4.50 with no trait label currently assigned in this dataset.

Trait associations

Every variant in this dataset with an assigned trait label points to cardiovascular traits. The cardiovascular category can encompass a range of heart and blood vessel phenotypes, though the specific condition or diagnosis tied to each individual rsid is not yet detailed in the available summaries. Notably, all 19 top-magnitude variants - including rs140716870, rs142375882, rs985916344, rs886039042, and rs74905373, among others - consistently resolve to this same trait domain. In genomic research, convergent signals across multiple independent variants within one gene are generally considered more meaningful than a single association in isolation.

Evidence quality

Detailed per-SNP research summaries - including study cohort sizes, odds ratios or beta coefficients, and replication status - have not yet been loaded for these variants. The dataset records 428 total PRKG1 variants, with 45 noted as having prior research summaries that are not yet displayed. Without individual study-level data, it is not possible to confirm whether these signals come from GWAS (genome-wide association study - a method that scans large numbers of people's genomes for variants statistically linked to a trait), clinical variant databases such as ClinVar, or single-cohort studies. The consistent magnitude of 5.50 across 19 variants in the same trait domain is notable, but the absence of replication and effect-size detail means these should be treated as pointers to published research rather than standalone conclusions.

What this is NOT

These variants are population-level statistical signals from group-level genomic studies - they describe tendencies observed across large populations, not outcomes for any specific individual. Nothing here constitutes medical advice, a diagnosis, or a recommendation for any action.