NRXN1, variants, traits, and what the research shows

NRXN1 - what this gene does

Based on the available variant data, NRXN1 is associated with rare disease trait categories across a large set of catalogued variants.

Key takeaways

• All 20 of the highest-magnitude variants on file for this gene are linked to rare disease traits
• This gene has 1,225 total variants catalogued - a large set by any measure
• Every listed variant carries a magnitude score of 5.50, reflecting a consistent evidence tier across the full listed set
• No per-variant research summaries are yet available, so detailed effect sizes and study designs cannot be compared here
• Population-level statistical signals cannot predict outcomes for any individual

Notable variants

The five top-ranked entries in the current catalogue - rs1039999157, rs1057520338, rs112536447, rs112638127, and rs113067443 - each carry a magnitude score of 5.50 and share a rare disease trait classification. Three additional variants at the same magnitude extend this pattern: rs1169668668, rs1259694734, and rs1285800435.

Trait associations

Every variant among the top 20 by magnitude - including rs1039999157, rs141566634, rs143446587, rs143495349, rs144049982, rs145558855, rs146100580, rs147580960, rs1476850082, and rs148764264 - is classified under the rare disease trait category. This uniform classification across the entire listed set represents a consistent, if broad, thematic signal.

Evidence quality

This gene has 1,225 variants on file in total; the 20 listed here are the highest-magnitude entries, all scoring 5.50. No per-variant research summaries are yet available in this resource, meaning specific effect sizes (such as odds ratios - the ratio of the odds of a trait appearing in variant carriers versus non-carriers), sample sizes, and replication status cannot be assessed at this time. Until SNP-level summaries are published, the individual strength and study design behind each association remains uncharacterized here.

What this is NOT

These variants represent population-level statistical signals observed across groups of people, not deterministic predictors of any individual's health or traits. This entry does not prescribe, diagnose, or advise any course of action.