MAPT, variants, traits, and what the research shows

MAPT - what this gene does

Variants catalogued in MAPT cluster around two broad trait themes: neurological conditions and rare diseases.

Key takeaways

• All 20 of the highest-ranked variants carry a magnitude score of 5.50 - the top tier of signal strength in this dataset.
• Associations split across two categories: neurological conditions (15 of the top 20 variants) and rare diseases (5 of the top 20).
• 381 total variants are on file, making this one of the more extensively catalogued gene loci in this database.
• Per-variant trait labels are not yet available - specific conditions will appear as data are added.
• These are population-level statistical associations, not deterministic predictions for any individual.

Notable variants

All 20 of the top-ranked variants share a magnitude score of 5.50. Among the neurological-category signals, rs115492908, rs1247408229, rs138293088, rs143624519, and rs148501218 represent prominent entries. On the rare disease side, rs63749855, rs568067396, rs199644237, rs200099007, and rs1401903524 carry equivalent magnitude scores. Because per-variant trait labels are not yet available in this dataset, the specific conditions associated with each rsid cannot be stated here.

Trait associations

Of the top 20 variants, 15 fall under the neurological trait category - including rs115492908, rs1247408229, rs143138715, rs1568327531, rs199759929, and rs377720312, among others - indicating a consistent neurological signal replicated across multiple independent variants in this gene. The five rare disease-category variants - rs1401903524, rs199644237, rs200099007, rs568067396, and rs63749855 - carry the same top-tier magnitude score as their neurological counterparts. The co-occurrence of both categories within this gene's highest-magnitude signals suggests the locus intersects with research across multiple distinct disease areas.

Evidence quality

The 20 highest-magnitude variants on file all score at 5.50 - the strongest tier in the current dataset. However, no per-variant trait labels, effect sizes (such as odds ratios or beta coefficients - measures of how strongly a variant shifts the statistical likelihood of a trait in a study population), or sample size data are currently available for these rsids in this database. With 381 total variants catalogued, coverage of this gene is broad, but the absence of underlying study-level detail means replication status and evidence depth for individual variants cannot be assessed at this time. Treat all associations as preliminary until full trait-level data are confirmed.

What this is NOT

The variants shown here are population-level statistical associations drawn from research studies - they are not deterministic predictors of disease or health outcomes for any individual. This entry does not prescribe, diagnose, or advise on any medical or personal action.