LYPLAL1-AS1, variants, traits, and what the research shows

LYPLAL1-AS1 - what this gene does

Variants near LYPLAL1-AS1 (LYPLAL1 antisense RNA 1) have been associated primarily with liver-related and metabolic traits in GWAS (genome-wide association studies - large-scale scans that look for variants statistically linked to a trait across many thousands of people's genomes). A single variant also carries a hormonal trait label. No functional mechanism for this gene is characterized in the current dataset.

Key takeaways

• The LYPLAL1-AS1 locus has 240 variants on file, with the two highest-magnitude signals linked to liver and metabolic traits respectively.
• Multiple independent variants at this locus point to metabolic traits, suggesting a recurring signal in that domain rather than a single-study artifact.
• One variant carries a hormonal trait flag - an isolated finding in the current dataset that warrants additional caution.
• All associations are population-level statistical signals from genome-wide studies, not deterministic predictions for any individual.
• Detailed effect sizes and replication data were not available for most variants in this entry.

Notable variants

The two highest-magnitude variants are rs1538742 (magnitude 4.50, liver trait) and rs553014999 (magnitude 4.50, metabolic trait) - the strongest signals on file for this locus. At magnitude 2.80, rs35662751 is also tagged to metabolic traits; rs2820465 and rs5781125 share the same magnitude but lack assigned trait labels in the current dataset. Within a cluster of magnitude-2.20 variants, rs11118303, rs11118304, rs11118308, and rs11118320 are linked to metabolic traits, while rs11118310 carries a hormonal trait label.

Trait associations

The dominant trait themes across this locus are liver-related conditions and metabolic traits. rs1538742 represents the strongest liver-associated signal (magnitude 4.50), while rs553014999 leads the metabolic signals at the same magnitude. The metabolic association recurs across multiple additional variants - including rs35662751 at magnitude 2.80 and rs11118303, rs11118304, rs11118308, and rs11118320 at magnitude 2.20 - suggesting this metabolic signal is not confined to a single data point. The hormonal trait association flagged for rs11118310 is a single isolated observation in the available data and should be interpreted with additional caution.

Evidence quality

The two top-ranked variants - rs1538742 and rs553014999 - carry magnitude scores of 4.50, which are relatively strong for GWAS-derived signals; however, detailed study metadata including sample sizes, effect sizes (such as odds ratios or beta coefficients), and replication cohort information were not available in the summaries provided for this entry. The cluster of magnitude-2.20 variants represents more modest associations typical of GWAS findings, and the absence of populated editorial content for the majority of published-page variants means their replication status and effect direction cannot be confirmed here. All associations at this locus should be treated as preliminary population-level signals pending independent replication.

What this is NOT

These variants are population-level statistical signals from genome-wide association studies and are not deterministic predictors of health outcomes for any individual. Nothing in this entry constitutes medical advice, a diagnosis, or a recommendation to take any action.