JMJD1C, variants, traits, and what the research shows

JMJD1C - what this gene does

JMJD1C is a human gene whose catalogued variants cluster around two broad trait themes: rare diseases and neurological conditions. Without detailed research summaries for the individual variants on file, a precise account of the gene's molecular function cannot be responsibly given here.

Key takeaways

• JMJD1C has nearly 1,000 catalogued genetic variants, with the highest-ranked entries linked to rare disease and neurological trait categories.
• All 20 top-ranked variants share the same evidence-strength score of 5.50, suggesting a consistent tier of research attention across the leading entries.
• Only one of the 20 top-ranked variants falls in the neurological category; the remaining 19 are linked to rare disease.
• Specific disease names and effect sizes are not yet available for these top-ranked variants - findings should be treated as preliminary.
• These are population-level statistical associations, not individual health predictions.

Notable variants

The highest-ranked entries on file all carry a magnitude score of 5.50. Among the rare disease associations, rs1241903352, rs144839482, rs145265323, rs189118006, and rs200368807 are representative examples. rs1847769670 stands apart as the sole neurological-category variant among the top-ranked entries. Further rare disease variants - including rs372628812 and rs529610837 - appear at the same magnitude level.

Trait associations

The dominant signal across the top-ranked entries points to rare disease, with 19 of the 20 highest-magnitude variants falling in that category - among them rs1241903352, rs144839482, rs145265323, rs1589150589, rs1589629026, rs1844718876, rs200874068, rs200927709, rs201371848, rs201514908, rs201696710, rs201896088, rs375835104, rs376656512, and rs562218545. A neurological association is present via rs1847769670. Specific disease or phenotype names are not derivable from the current data.

Evidence quality

Close to 1,000 variants are catalogued for this gene, of which 67 have been flagged as having prior research attention; however, no individual variant summaries are available at this time, limiting how deeply each signal can be characterised. All 20 top-ranked variants share a magnitude of 5.50, indicating a consistent evidence tier at the head of the list, but without effect sizes (such as odds ratios - the relative likelihood of a trait given a particular genotype - or regression beta coefficients), sample sizes, or replication data, the practical weight of these signals cannot be fully assessed. All findings here should be treated as preliminary pending fuller annotation.

What this is NOT

Every variant listed here is a population-level statistical signal from genetic research - a GWAS (genome-wide association study, a method that scans many people's genomes for variants statistically linked to a trait) finding does not determine any individual's health outcome. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.