IFNG-AS1, variants, traits, and what the research shows

IFNG-AS1 - what this gene does

Based on the variants catalogued here, IFNG-AS1 (also referred to as IFNG antisense RNA 1) shows associations across several trait domains, most prominently immune-related conditions and rare disease categories, with additional signals in mental health and respiratory traits.

Key takeaways

• Variants in this gene have been linked to immune-related traits, rare disease categories, and mental health domains in genome-wide research.
• Two separate variants associate with mental health traits, suggesting a repeated signal in that domain.
• Five or more variants connect to immune-related trait categories, spanning multiple magnitude tiers.
• Additional signals include respiratory, cardiovascular, liver, metabolic, hormonal, and coagulation trait associations.
• All associations are population-level statistical signals, not deterministic predictors for any individual.

Notable variants

The highest-magnitude variants on file carry scores of 4.50. Among these, rs115495897 is linked to a rare disease trait category, rs2041862 to immune traits, and rs6581787 to mental health traits. Two variants without trait metadata, rs34906074 and rs75541908, also reach this magnitude tier. At magnitude 2.80, rs12321565 adds a second independent mental health signal, rs1558744 points to immune traits, and rs183884080 is associated with respiratory traits.

Trait associations

Immune-related traits appear across multiple variants: rs2041862 (magnitude 4.50), rs1558744 (magnitude 2.80), rs10784676 (magnitude 2.20), rs12825700 (magnitude 2.20), and rs140032011 (magnitude 2.20). The mental health category is represented by both rs6581787 (magnitude 4.50) and rs12321565 (magnitude 2.80), with the same trait domain appearing in two independent variants. Respiratory traits are linked to rs183884080 (magnitude 2.80). Among lower-magnitude signals, rs10784685 is associated with cardiovascular traits, rs10878763 with liver traits, rs12366377 with metabolic traits, rs10784681 with hormonal traits, and rs1118865 with coagulation traits.

Evidence quality

A total of 45 variants are on file for this gene, of which 17 have associated research summaries. Magnitude scores range from 2.20 to 4.50, with the stronger signals (4.50) concentrated in rare disease, immune, and mental health trait categories. The appearance of mental health associations across two separate variants (rs6581787 and rs12321565) and immune associations across at least five variants provides some within-dataset replication. However, the dataset does not include sample size, cohort count, or study design detail for these associations, so the extent of external replication across independent cohorts cannot be confirmed here. These associations are characteristic of GWAS (genome-wide association study - a study that scans many people's genomes for variants statistically associated with a trait) signals and should be treated as preliminary population-level findings.

What this is NOT

The variants described here are population-level statistical associations from research studies and are not deterministic predictors of any outcome for any individual. This entry does not constitute medical advice, a diagnosis, or a recommendation of any kind.