rs10784685 - IFNG-AS1
Magnitude 2.2 · 1 study on file
Reported associations
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Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits - Unknown journal (n.d.) · Unknown authors · PubMed 33603002
ABSTRACT: Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS based on longitudinal BP have been underexplored. We performed ethnic-specific and trans-ethnic GWAS meta-analysis using longitudinal and cross-sectional BP data of 33,720 individuals from five cohorts in the US and one in Brazil. In addition to identifying several known loci, we identified thirteen novel loci with nine based on longitudinal and four on cross-sectional BP traits. Most of the novel loci were ethnic- or study-specific, with the majority identified in African Americans (AA). Four of these discoveries showed additional evidence of association in independent datasets, including an intergenic variant (rs4060030, p
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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blood pressure trajectory risk stratification Moderate
Genetic association with accelerated BP change suggests individualized cardiovascular risk assessment is warranted
Discuss genetic cardiovascular risk and monitoring strategy with healthcare provider
Lifestyle
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cardiovascular disease prevention program Moderate
T allele carriers show elevated blood pressure trajectory; comprehensive lifestyle intervention can help offset genetic predisposition
Implement exercise, diet, weight management, and stress reduction per physician guidance
Screening
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systolic blood pressure monitoring Moderate
rs10784685 T allele associates with steeper systolic blood pressure trajectory over time, indicating future cardiovascular risk escalation
Establish baseline BP and monitor at least annually; discuss trend tracking with physician