GRID1, variants, traits, and what the research shows

GRID1 - what this gene does

Variants within this gene have been linked to trait categories including rare disease, kidney conditions, cancer, athletic performance, and mental health; the specific biological function is not captured in the current variant data.

Key takeaways

• The highest-magnitude variant on file is linked to a rare disease trait, making it the most prominent signal in this dataset
• Separate variants connect this gene to kidney conditions, cancer, athletic performance, and mental health - a notably broad trait spread for a single locus
• Rare disease signals appear across multiple variants at different magnitude levels, suggesting a recurring research theme
• Effect sizes and sample sizes are not provided in the current dataset, so evidence precision cannot be fully assessed
• All associations are population-level statistical findings from genomic studies - not individual health predictions

Notable variants

The variant with the largest recorded magnitude is rs754921053 (magnitude 5.50), linked to a rare disease trait. Among the next tier, rs11201829 carries a kidney-trait association and rs11201919 a cancer-trait association - both at magnitude 4.50. Athletic performance appears at rs569475444 (magnitude 4.50), and a mental health signal is noted at rs78092837 (magnitude 4.50). At magnitude 3.00, rare disease associations recur across rs118168995, rs1185527979, rs1282622742, and rs1349977226.

Trait associations

Rare disease is the most prominent and most repeated trait theme in this dataset. The signal is anchored by rs754921053 at magnitude 5.50 - the highest on file - and reinforced by four magnitude 3.00 variants (rs118168995, rs1185527979, rs1282622742, rs1349977226) also carrying rare disease annotations; replication across multiple independently listed variants strengthens this theme within the dataset. Kidney-related traits appear through rs11201829 and cancer-related traits through rs11201919, each at magnitude 4.50. Athletic performance is associated with rs569475444 and mental health with rs78092837, both at magnitude 4.50. Several additional magnitude 4.50 variants (rs184274255, rs1970525, rs2140663, rs2352179, rs572482355, rs6585998) and multiple magnitude 3.00 variants carry no trait label in the current dataset.

Evidence quality

A total of 179 variants are on file for this gene, with 22 carrying prior research summaries; detailed editorial content for individual variants is not yet available in this entry. No effect sizes (such as odds ratios or beta coefficients) or cohort sample sizes are provided in the current dataset, so statistical precision and replication status cannot be assessed here. The strongest signal by magnitude - rs754921053 at 5.50, rare disease - stands out within the dataset, but without attached cohort data it should be regarded as preliminary. The most internally consistent finding is the recurrence of rare disease associations across five independently listed variants, which within this dataset represents the most replicated theme.

What this is NOT

These variants are population-level statistical signals identified in genomic research - they reflect group-level probabilities and are not deterministic predictors for any individual. Nothing on this page constitutes medical advice, a clinical diagnosis, or a recommendation to take any action.