rs11201829 - GRID1
Magnitude 4.5 · 1 study on file
Reported associations
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Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients - Unknown journal (n.d.) · Unknown authors · PubMed 32238385
ABSTRACT: Objectives Genome-wide meta-analyses of clinically defined gout were performed to identify subtype-specific susceptibility loci. Evaluation using selection pressure analysis with these loci was also conducted to investigate genetic risks characteristic of the Japanese population over the last 2000-3000 years. Methods Two genome-wide association studies (GWASs) of 3053 clinically defined gout cases and 4554 controls from Japanese males were performed using the Japonica Array and Illumina Array platforms. About 7.2 million single-nucleotide polymorphisms were meta-analysed after imputation. Patients were then divided into four clinical subtypes (the renal underexcretion type, renal overload type, combined type and normal type), and meta-analyses were conducted in the same manner.
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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gout prevention and uric acid management Moderate
GRID1 variant increases gout risk via impaired renal urate clearance
discuss preventive strategies and consider uric acid monitoring
Lifestyle
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hydration and gout trigger avoidance Moderate
Adequate hydration supports renal urate clearance; alcohol and dehydration trigger gout attacks
maintain daily fluid intake above 2 liters; limit alcohol consumption
Screening
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serum uric acid levels Moderate
GRID1 variant impairs renal urate excretion, increasing gout risk
baseline serum uric acid test, repeat annually or if symptoms develop