GNPTAB, variants, traits, and what the research shows

GNPTAB - what this gene does

All variants currently on file for GNPTAB point to metabolic trait associations. Without individual SNP summaries available for this gene, detailed mechanistic claims cannot be made, but the consistent metabolic theme across 701 catalogued variants indicates this gene has a meaningful presence in metabolic research.

Key takeaways

• All catalogued variants for GNPTAB are associated with metabolic traits
• The top-ranked variants carry a magnitude score of 5.50, a high-priority weighting in the dataset
• 701 variants are on file, suggesting a broad research footprint at this genomic location
• Detailed SNP-level summaries are still being added to this entry, so specific trait names within the metabolic category are limited here
• These are population-level statistical patterns, not personal health predictions

Notable variants

The highest-magnitude entries in the current dataset include rs1020172077, rs111863978, rs112543062, rs1185319004, and rs1201536920, each scored at magnitude 5.50 and linked to metabolic traits. Further variants sharing this same magnitude and trait profile include rs137852896, rs137852897, rs138811990, and rs141329633.

Trait associations

Every variant catalogued for this gene carries a metabolic trait label. The consistent presence of metabolic associations across entries such as rs1235685630, rs1244017657, rs1245543262, rs141529327, and rs1288191896 reinforces this theme. Because all 20 top-ranked variants point to the same trait category, the metabolic signal here is notably consistent, though specific condition names within that category are not yet detailed in this dataset.

Evidence quality

All variants in this dataset carry a uniform magnitude score of 5.50. Individual SNP-level research summaries have not yet been loaded for this gene, which means specific odds ratios (a measure of how much a variant statistically increases or decreases the likelihood of a trait), effect directions, and population sample sizes cannot be reported here. Without those summaries, single-cohort versus multi-cohort replication status and GWAS (genome-wide association study, a type of research that scans many people's genomes for variants statistically associated with a trait) confidence levels also cannot be assessed. The 701 total variants on file suggest a substantial research footprint, but this entry should be treated as a preliminary index until fuller annotations are available.

What this is NOT

These variants are population-level statistical signals, not deterministic predictors for any individual. This page does not prescribe, diagnose, or advise any course of action.