DNM3, variants, traits, and what the research shows

DNM3 - what this gene does

Variants in DNM3 have been statistically associated with two broad trait themes: mental health and blood coagulation (the biological process by which blood forms clots). No research summaries are available for these specific variants in the current dataset, so the description below is grounded solely in the trait labels and magnitude scores attached to the highest-ranked signals on file.

Key takeaways

• Two of the five highest-ranked variants are linked to mental health traits.
• One of the five highest-ranked variants is linked to blood coagulation traits.
• The top-magnitude variants all score 4.50 - among the stronger signals recorded for this gene.
• 252 variants are on file, with 59 noted as carrying prior research context, though none were available for this entry.
• All associations are population-level statistical signals, not deterministic predictors for any individual.

Notable variants

The five highest-magnitude variants each carry a score of 4.50. rs6425479 and rs742510 are tagged with mental health trait associations, while rs76257386 is tagged with a coagulation trait association. rs590567 and rs678962 reach the same magnitude threshold but carry no trait label in the current dataset. A further fifteen variants - among them rs1291452147, rs1313104093, rs1345200287, rs1350184812, and rs1446545746 - sit at magnitude 3.00 with no assigned trait labels.

Trait associations

Two trait domains are represented in the top-magnitude tier. Mental health is the trait label for rs6425479 and rs742510; its appearance across two independently catalogued variants at the same top tier is notable, though independent replication data is not available here to confirm the signal. Coagulation is the trait label for rs76257386, also at the top tier. Because no detailed research summaries are provided for these variants, specific diagnoses, conditions, or effect sizes cannot be named.

Evidence quality

No SNP-level research summaries were provided for this gene; all observations here derive from variant rsids, magnitude scores, and broad trait labels. Of the 252 variants on file, 59 are noted as having prior research context in the broader database, but none of that material was available for this entry. Without study metadata - such as sample sizes, odds ratios, or cohort descriptions - the strength of individual signals cannot be fully assessed. The co-occurrence of mental health and coagulation labels at the highest-magnitude tier is a preliminary observation and should be treated as hypothesis-generating until detailed study summaries are incorporated.

What this is NOT

The variants described here are population-level statistical associations from genome-wide research (studies that scan many people's genomes for variants statistically linked to a trait) - not deterministic predictors of any outcome for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.