CTNNA2, variants, traits, and what the research shows

CTNNA2 - what this gene does

Variants in CTNNA2 (with 203 total variants catalogued in our database, 18 of which have associated research summaries) have been linked in genetic research to three broad trait themes: neurological conditions, cancer-related phenotypes, and mental health. The data on file does not provide sufficient detail to characterize the gene's molecular function, but the pattern of associations across many independent variants suggests broad biological relevance spanning multiple body systems.

Key takeaways

• CTNNA2 has 203 catalogued variants, with the strongest signals pointing to neurological and cancer-related traits.
• Four of the five highest-scoring variants in this gene are linked to neurological conditions, suggesting this is the gene's most prominent area of association.
• Cancer-related traits appear across at least four separate variants, broadening the picture beyond neurology alone.
• A mental health association is also on file, alongside liver and nutrition-related signals, rounding out a wide trait profile.
• All findings are population-level statistical signals from genetic research, not individual-level predictions.

Notable variants

The five highest-magnitude variants on file for this gene all score 5.50. Four of them, rs1413537928, rs2468044149, rs760139097, and rs778294237, are each linked to neurological traits, while rs2104990962 carries a cancer-related association at the same magnitude level. A magnitude-5.00 variant, rs2467103861, also points to neurological conditions. Among the magnitude-4.50 tier, rs10180106 is linked to a mental health phenotype, rs2862025 adds another neurological signal, and rs112716246, rs138150808, and rs183480050 each carry cancer-related labels.

Trait associations

Neurological conditions appear most frequently across variants in this gene. Multiple independent variants, including rs1413537928, rs2468044149, rs760139097, rs778294237, rs2467103861, rs1368908, and rs2862025, all carry neurological trait labels. Repeated association across multiple independent variants is meaningful in genetic research, as it reduces the likelihood that any single finding is a statistical artifact.

Cancer-related traits also appear across multiple variants: rs2104990962, rs112716246, rs138150808, and rs183480050 all carry cancer labels. Additional associations include a mental health phenotype at rs10180106, a liver-related trait at rs139283309, and a nutrition-related association at rs2100290.

Evidence quality

The prior editorial summaries for the four variants with published pages in this gene, rs10180106, rs112716246, rs112924349, and rs115416830, are not yet available in sufficient detail to characterize study designs, sample sizes, or replication status. The magnitude scores in the variant list indicate relative signal strength within our database, but without full summary statistics such as odds ratios, confidence intervals, or cohort sizes, the absolute evidence quality for any individual variant cannot be assessed here. The findings listed reflect GWAS (genome-wide association studies, research that scans many people's genomes for variants statistically associated with a trait) methodology, and most should be treated as preliminary population-level signals pending fuller annotation.

What this is NOT

These variants are population-level statistical signals identified in large-scale genetic studies, not deterministic predictors of any health outcome for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.