rs112924349 - CTNNA2
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide association study identifies novel caries-associated loci showing sex-specificity-A study on the Northern Finland Birth Cohort 1966. - European journal of oral sciences (2023) · Laajala A, Pesonen P, Alaraudanjoki V, Anttonen V, Laitala ML · PubMed 37707347
A genome-wide association study was performed in sex-stratified groups representing three different caries phenotypes among adults. The study sample consisted of 46-year-old participants of the Northern Finland Birth Cohort 1966 study (n = 1481). The phenotypes for analyses were the dentin caries phenotype (persons having at least one tooth with dentin caries lesion), and the enamel caries phenotype (those having teeth with more than 10 enamel caries lesions), while the control group had <10 enamel caries lesions and no teeth with dentin caries, respectively. A third phenotype dubbed the caries severity phenotype had a below-average number of teeth with initial lesions and at least one extensive dentin caries lesion; their controls had an above-average number of teeth with initial carie
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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high-frequency sugar consumption Moderate
G allele increases caries susceptibility; dietary sugar is the primary modifiable driver of caries risk
Limit added sugars, especially between meals and in beverages
Screening
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dental caries screening frequency Moderate
CTNNA2 G allele associated with significantly increased caries severity, indicating higher baseline caries risk
Increase dental visit frequency to every 6 months instead of annually