CCDC26, variants, traits, and what the research shows

CCDC26 - what this gene does

Variants catalogued in or near CCDC26 span several trait domains - with cancer-related associations appearing most frequently, followed by signals in musculoskeletal, liver, neurological, and immune categories. Because published research summaries for individual variants do not yet contain detailed functional content, this entry characterizes the gene through its pattern of trait associations.

Key takeaways

• Three separate high-magnitude variants are linked to cancer - the most repeated single-trait signal in this gene's catalogue
• Musculoskeletal traits appear in two variants at the same top magnitude tier
• Liver, neurological, and immune trait signals are also on file
• All associations come from population-level genetic studies and describe statistical patterns across groups, not individual outcomes
• 255 variants are catalogued for this gene; research summaries are being added progressively

Notable variants

The highest-tier variants on file all share a magnitude of 4.50. The most consistent signal comes from three cancer-linked variants: rs55705857, rs72714236, and rs72714270. Musculoskeletal associations appear in rs10956445 and rs144444502. A liver-related signal is recorded for rs1372448, a neurological signal for rs74305956, and an immune signal for rs78657238. Two variants with published pages - rs112704402 and rs116919579 - currently carry no trait label in their records. Several additional magnitude-4.50 entries, including rs1372449, rs1519844, and rs987525, are likewise catalogued without current trait annotations.

Trait associations

Cancer is the best-represented trait category, with three distinct variants - rs55705857, rs72714236, and rs72714270 - each carrying that annotation at the highest magnitude tier. Having multiple independent variants in the same genomic region linked to the same broad trait is generally considered a stronger signal than a single hit, though without detailed study metadata it is not yet possible to confirm whether these reflect fully independent findings or correlated variants from a shared study. Musculoskeletal phenotypes are tagged in rs10956445 and rs144444502. Liver (rs1372448), neurological (rs74305956), and immune (rs78657238) traits each appear once at the same high magnitude. Two lower-magnitude variants - rs13271259 and rs17262815 - are on file at magnitude 2.80 without current trait labels.

Evidence quality

All 18 top-tier variants share a magnitude of 4.50, reflecting meaningful effect size or evidence weight in the source data. However, the individual research summaries for the three variants with published pages - rs112704402, rs116919579, and rs10956445 - contain no detailed content in the current record, so odds ratios, sample sizes, study cohorts, and replication status cannot be reported here. The three-variant cancer cluster is the most internally consistent signal, but without cross-study confirmation it remains a pointer to the literature rather than a fully grounded finding. Approximately half of the listed high-magnitude variants carry no trait label at all, and the two lower-magnitude entries are similarly unannotated. This entry will be updated as individual SNP summaries are filled in.

What this is NOT

These variants are population-level statistical signals from genome-wide association studies (GWAS - research that scans large numbers of people's genomes for variants statistically linked to traits); they describe tendencies across populations, not deterministic outcomes for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.