CALN1, variants, traits, and what the research shows

CALN1 - what this gene does

Variants associated with CALN1 appear across several disease and trait categories in the genetic research on file, with neurological conditions representing the most consistent theme across multiple independent signals.

Key takeaways

• Six separate variants in CALN1 are each linked to neurological traits - more than any other single category in this dataset.
• Two variants connect this gene to mental health associations.
• Single variants also link it to rare disease, kidney conditions, and cancer - these are preliminary, single-signal findings.
• All top-ranked variants share the same evidence tier; no one variant dominates the signal.
• These associations are population-level statistical patterns, not predictions for any individual.

Notable variants

The best-evidenced variants in this gene all carry a magnitude score of 4.50. Among neurological signals, rs10227076, rs147403806, rs34711194, rs55841409, rs865225, and rs9638655 each link the gene to neurological traits - six independent variants converging on the same category. Two variants - rs56150095 and rs7808347 - point toward mental health associations at the same evidence tier. rs10241320 carries a rare-disease flag, rs139550257 appears in cancer-related research, and rs147005985 in kidney-related research.

Trait associations

Neurological traits are the dominant category, with six magnitude-4.50 variants - rs10227076, rs147403806, rs34711194, rs55841409, rs865225, and rs9638655 - all labeled with this theme. When multiple independent variants in a gene converge on the same trait, it lends modest additional support to that gene's relevance in that area - though it does not confirm causation. Mental health associations appear in rs56150095 and rs7808347, providing a second recurring theme. Rare disease (rs10241320), kidney traits (rs147005985), and cancer (rs139550257) each appear in a single variant and should be treated as preliminary signals pending independent replication.

Evidence quality

The dataset contains 125 variants in total, with 20 carrying prior research documentation; 14 of the top-ranked variants all sit at a magnitude score of 4.50, indicating a broadly consistent evidence tier rather than one standout signal. The neurological association benefits from convergence across six independent variants - a modest but meaningful form of internal replication within a single gene. However, specific effect sizes (such as odds ratios or beta coefficients), cohort sample sizes, and external replication status are not available in the current data for individual variants. Single-signal findings - particularly for cancer, kidney, and rare disease - carry heightened uncertainty and should be treated cautiously until confirmed in independent cohorts.

What this is NOT

The variants described here are population-level statistical associations from GWAS studies (genome-wide association studies - research that scans many thousands of genomes to identify DNA variants statistically linked to a trait), not deterministic predictors of any individual's health. This page does not prescribe, diagnose, or advise.