rs10241320 - CALN1
Magnitude 4.5 · 1 study on file
Reported associations
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Genetic study identifies novel genes in developmental dysplasia of the hip - Unknown journal (n.d.) · Unknown authors · PubMed 41912496
ABSTRACT: Developmental dysplasia of the hip (DDH), a morphological abnormality of the hip joint, is a well-recognized risk factor for hip osteoarthritis (OA). Much remains unknown about the genetic factors of DDH and its subtypes. To further understand its genetic basis, we conducted genome-wide association studies (GWASs) using a total of 1 085 Japanese DDH cases (including 788 hip dysplasia cases without dislocation and 297 cases with dislocated hip) and 24 000 controls. Additionally, we meta-analyzed with United Kingdom (UK) DDH GWAS and the largest hip OA GWAS to date. We identified three genome-wide significant novel loci, COL11A2, CALN1 and TRPM7, associated with hip dysplasia without dislocation. None of these signals were significant in dislocated hips, and additionally two of the
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Hip-friendly newborn positioning and diaper practices Moderate
Risk allele increases hip dysplasia susceptibility; environmental measures including proper positioning and hip-movement-allowing diapers reduce dysplasia incidence from 5.4% to 0.1%
Use hip-friendly diapers, avoid restrictive swaddling of hips, ensure legs can move freely in natural flexion/abduction position