BABAM2, variants, traits, and what the research shows

BABAM2 - what this gene does

BASAM2 (BRCA1-associated protein affecting mitosis 2; also referred to as BABAM2) is a human gene whose catalogued variants are linked, in genome-wide association research, to two broad trait categories: cancer and metabolic conditions. No functional mechanism can be characterized from the data currently on file - the description below is grounded solely in the variant trait labels available.

Key takeaways

• Two variants reach the highest magnitude score on file and are linked to a cancer trait and a metabolic trait, respectively.
• A second, independent cancer-associated signal adds further depth to this gene's cancer-linked profile.
• Most of the 152 catalogued variants carry no published trait annotation in the current dataset.
• Detailed effect sizes and replication data are not yet available, so the strength of these associations cannot be fully assessed.
• All signals here are population-level statistics; they cannot predict outcomes for any individual.

Notable variants

Four variants reach the top magnitude score of 4.50 on file. Among those with trait labels, rs144118728 is linked to a cancer-related trait and rs34922334 is linked to a metabolic trait - both at magnitude 4.50. Two further high-magnitude variants, rs6721691 and rs6737205, also score 4.50 but currently carry no trait annotation. Stepping down to magnitude 3.00, rs193920803 provides a second cancer-associated signal, and a cluster of additional magnitude-3.00 variants - including rs138608273, rs201837586, rs202064486, rs367605362, and rs748807354 - rounds out the catalogued set, though none of those carry trait annotations in the current data.

Trait associations

The two represented trait themes are cancer and metabolic conditions. Cancer associations appear across at least two distinct variants: rs144118728 at the top magnitude tier and rs193920803 at the next tier. When two or more independent variants in the same gene surface in cancer-related GWAS (genome-wide association study - a method that scans large populations for genetic variants statistically linked to a trait) findings, it can indicate a more robust locus-level signal, though replication in independent cohorts is required before drawing firm conclusions. The metabolic-trait association rests on a single high-magnitude variant, rs34922334, and should be treated as a preliminary signal until further evidence accumulates. The remaining 149-plus catalogued variants have no trait annotation on file.

Evidence quality

No study summaries are available for this gene in the current dataset, meaning effect sizes (such as odds ratios or beta coefficients), sample sizes, and replication status cannot be reported. Trait labels exist for only three of the 152 catalogued variants - two tagged as cancer-related (rs144118728 and rs193920803) and one as metabolic (rs34922334). The magnitude scores reflect an internal ranking that combines effect size and evidence strength, but they do not substitute for published summary statistics. The cancer signal spanning two variants is the strongest structural observation currently available; all other associations should be considered uncharacterized pending further annotation.

What this is NOT

The variants catalogued here are population-level statistical signals from large genetic studies and are not deterministic predictors of any health outcome for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation of any kind.