ANK3, variants, traits, and what the research shows

ANK3 - what this gene does

Variants in ANK3 (also recorded as ankyrin 3) cluster around two trait themes visible in current research data: sleep-related traits and rare disease categories. No variant-level study summaries are yet loaded for this gene, so the observations below reflect only the signal patterns visible in the variant list itself.

Key takeaways

• ANK3 carries variants associated with both sleep-related traits and rare disease categories
• All highlighted variants share an identical magnitude score of 5.50, indicating consistent signal strength across both trait themes
• 817 total variants are on file, with sleep and rare disease associations appearing across multiple independent rsids - suggesting breadth rather than a single dominant signal
• These are population-level statistical associations, not deterministic predictors for any individual
• Detailed study metadata for specific variants is not yet available in this dataset

Notable variants

Among the sleep-associated variants, rs1064796340, rs117475706, rs12260663, and rs139022925 each carry a magnitude of 5.50. On the rare disease side, rs116757606, rs138073935, rs139379111, and rs140346169 share the same magnitude score. The even distribution of signal strength across both trait categories means no single variant clearly dominates the others in this dataset.

Trait associations

Sleep-related traits appear across ten variants in the current dataset: rs1064796340, rs117475706, rs12260663, rs139022925, rs139982397, rs140183285, rs140741466, rs141251507, rs144270555, and rs144465058, each at magnitude 5.50. Rare disease associations are equally represented, with rs116757606, rs138073935, rs138631688, rs139379111, rs140346169, rs140830125, rs141713197, rs142673853, rs144051466, and rs147219129 all in that category. The recurrence of this gene across two distinct research domains is a pattern worth noting, though it requires per-variant study data to interpret meaningfully.

Evidence quality

No variant-level study metadata - including sample sizes, cohort descriptions, effect sizes such as odds ratios or beta coefficients, or replication status - is currently available for ANK3 variants in this dataset. The 817 total variants on file include 37 flagged as having prior research summaries, but those summaries are not yet loaded. What the data does show is a consistent magnitude score of 5.50 across all 20 listed variants, spanning two trait themes. Until per-variant study details are available, the evidence quality for any specific biological or clinical claim cannot be assessed - treat the trait-theme associations as preliminary pointers rather than established findings.

What this is NOT

These variants are population-level statistical signals - a GWAS (a study that scans many people's genomes for variants statistically associated with a trait) hit in a large cohort does not predict any outcome for a specific individual. Nothing in this entry constitutes medical advice, a diagnosis, or a recommendation to take any action.