ALDH1A2, variants, traits, and what the research shows

ALDH1A2 - what this gene does

ALDH1A2 (aldehyde dehydrogenase 1 family member A2) has variants on file that cluster primarily around cardiovascular traits, with additional associations touching mental health and kidney function. No detailed SNP-level summaries are yet available for this gene's individual variants, so specific effect sizes, study designs, and replication status cannot be reported at this time.

Key takeaways

• The three highest-ranked variants in this gene all point to cardiovascular traits.
• One variant is linked to mental health and one to kidney function.
• Cardiovascular signals appear across multiple variants and magnitude levels, suggesting a consistent theme in the research.
• Several variants carry high magnitude scores but no trait label yet - the picture is incomplete.
• All associations are statistical patterns observed in large populations, not personal health predictions.

Notable variants

rs141245344, rs2504837607, and rs749124508 each carry a magnitude score of 5.50 - the highest in this dataset - and are all tagged to cardiovascular traits, forming the strongest and most concentrated signal in the gene. Stepping down to magnitude 4.50, rs1532085 is the sole variant carrying a mental health association, while rs77009789 is linked to kidney function. The cardiovascular cluster at this tier is reinforced by rs261316, rs2704190, and rs4471613.

Trait associations

Cardiovascular traits dominate this gene's variant landscape, appearing across seven distinct variants - rs141245344, rs2504837607, rs749124508, rs261316, rs2704190, rs4471613, and rs201056912 - spanning magnitude levels from 3.00 to 5.50. The recurrence of cardiovascular signals across multiple variants and magnitude tiers is noteworthy, though effect sizes and study details are not yet available to quantify the strength of individual associations. Mental health emerges through rs1532085, and kidney function through rs77009789. A set of magnitude-4.50 variants - rs33960206, rs4646623, rs532304547, rs62001712, and rs77828167 - currently carry no trait label in this dataset and should be considered uncharacterized pending further annotation.

Evidence quality

Detailed SNP-level summaries - including study designs, sample sizes, odds ratios, and replication status - are not yet loaded for these variants. The magnitude scores visible here combine effect size and evidence strength; the three cardiovascular-tagged variants at 5.50 represent the strongest recorded signals in this gene. Without summary metadata it is not possible to distinguish GWAS (genome-wide association study - a large scan of many thousands of genomes for variants statistically linked to a trait) findings from ClinVar (a curated database of clinically reviewed variants) entries, nor to confirm whether any of these signals have been replicated across independent cohorts. Of 337 total variants on file, 53 carry prior research summaries that will be surfaced as individual SNP pages are published; until then, all associations on this page should be treated as provisional.

What this is NOT

These variants are population-level statistical associations and are not deterministic predictors of any outcome for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation of any kind.