Expressive

rs12455370 - TMEM241, CABLES1

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genomic Insights Into Inflammatory Bowel Disease in United States Hispanic Participants: An Ancestry-Focused Study. - Gastroenterology (2026) · Beecham AH, McGovern DPB, Brugger SW, Davis MF, Torres EA, Gomez L, Li D, Lopez-Marte P, Daly MJ, Stevens C, Yang S, Sinha S, Mengesha E, Leavitt J, Damas OM, Quintero MA, Targan SR, Rabizadeh S, Sabic K, Cho JH, Abreu MT, McCauley JL, Haritunians T · PubMed 41661118

    Genetic admixture of United States Hispanic individuals provides a unique opportunity to examine ancestral origins of inflammatory bowel disease (IBD) risk. In ∼7.3K Hispanic participants (1660 IBD cases; 5614 controls), we examined ancestral heterogeneity of IBD clinical phenotypes and sought to identify IBD risk loci that displayed heterogeneity of effect or were ancestry-specific. Association of genetic ancestry with clinical phenotypes was evaluated. We conducted an ancestry-informed genome-wide (GW) association study for IBD, ulcerative colitis, and Crohn's disease (CD) to obtain ancestry-specific effect size estimates for alleles from African (AFR), European (EUR), and Amerindian (AIAN) origin. Ancestry-specific replication was assessed in All of Us Hispanic participants and transf

  • GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer - Unknown journal (n.d.) · Unknown authors · PubMed 34021172

    ABSTRACT: Genetic studies have examined body-shape measures adjusted for body mass index (BMI), while allometric indices are additionally adjusted for height. We performed the first genome-wide association study of A Body Shape Index (ABSI), Hip Index (HI) and the new Waist-to-Hip Index and compared these with traditional indices, using data from the UK Biobank Resource for 219,872 women and 186,825 men with white British ancestry and Bayesian linear mixed-models (BOLT-LMM). One to two thirds of the loci identified for allometric body-shape indices were novel. Most prominent was rs72959041 variant in RSPO3 gene, expressed in visceral adipose tissue and regulating adrenal cell renewal. Highly ranked were genes related to morphogenesis and organogenesis, previously additionally linked to can

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.