Expressive

rs1245463 - NOVA1-DT

Magnitude 2.2 · 2 studies on file

Reported associations

  • Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline - Unknown journal (n.d.) · Unknown authors · PubMed 40374629

    ABSTRACT: Large-scale genomic studies focusing on the genetic contribution to human aging have mostly relied on cross-sectional data. With the release of longitudinally curated aging phenotypes by the UK Biobank (UKBB), it is now possible to study aging over time at genome-wide scale. In this work, we evaluated the suitability of competing models of change in realistic simulation settings, performed genome-wide association scans on simulation-validated measures of age-related deweekcline, and followed up with LD-score regression and Mendelian Randomization (MR) analyses. Focusing on global cognitive and physical function, we observed marked differences between baseline function (θ) and accelerated decline (Δ). Both outcomes showed distinct heritability levels (e.g., 31.38% versus 3.15%

  • Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles - Unknown journal (n.d.) · Unknown authors · PubMed 35115687

    ABSTRACT: Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are previously unknown. These loci provide an opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes: migraine with aura and migraine without aura. Stratification of the risk loci using 29,679 cases with subtype information indicated three risk variants that seem specific for migraine with aura (in HMOX2, CACNA1A and MPPED2), two that seem specific for migraine without aura (near SPINK2 and near FECH) and nine that increase susceptibility for migraine regardless of subtype. The new risk loci include

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • adequate hydration Moderate

    Dehydration is a known migraine trigger; rs1245463 carriers have higher predisposition

    drink 8-10 glasses water daily, adjust for activity level

Discuss with your doctor

  • personalized migraine prevention strategies Moderate

    rs1245463 A allele carriers have elevated migraine risk

Exercise

  • regular aerobic exercise Moderate

    Exercise reduces migraine frequency; rs1245463 carriers have higher predisposition

    150 minutes moderate intensity aerobic activity weekly

Lifestyle

  • consistent sleep schedule Moderate

    Sleep disruption is a known migraine trigger; rs1245463 carriers have higher predisposition

    7-9 hours nightly at consistent times

  • stress management techniques Moderate

    Stress is a known migraine trigger; rs1245463 carriers have higher predisposition

    daily meditation, yoga, or progressive relaxation

Screening

  • migraine symptoms and patterns Moderate

    rs1245463 A allele is associated with increased migraine susceptibility

    track frequency, duration, severity, and triggers