Expressive

rs12453376 - ZZEF1

Magnitude 2.2 · 1 study on file

Reported associations

  • A cross-population atlas of genetic associations for 220 human phenotypes. - Nature genetics (2021) · Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A, Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y · PubMed 34594039

    Current genome-wide association studies do not yet capture sufficient diversity in populations and scope of phenotypes. To expand an atlas of genetic associations in non-European populations, we conducted 220 deep-phenotype genome-wide association studies (diseases, biomarkers and medication usage) in BioBank Japan (n = 179,000), by incorporating past medical history and text-mining of electronic medical records. Meta-analyses with the UK Biobank and FinnGen (n = 628,000) identified ~5,000 new loci, which improved the resolution of the genomic map of human traits. This atlas elucidated the landscape of pleiotropy as represented by the major histocompatibility complex locus, where we conducted HLA fine-mapping. Finally, we performed statistical decomposition of matrices of phenome-wid

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • carbohydrate quality and glycemic index Moderate

    Genetic T2D risk can be partially offset through dietary patterns that improve glucose homeostasis

    Prioritize whole grains, legumes, non-starchy vegetables; limit refined carbohydrates

Discuss with your doctor

  • type 2 diabetes risk and screening strategy Moderate

    Genetic risk variant warrants individualized discussion of screening frequency and prevention strategy

Exercise

  • regular physical activity for insulin sensitivity Moderate

    Physical activity improves insulin sensitivity and glucose tolerance, reducing T2D progression risk

    150 minutes weekly moderate-intensity aerobic activity; 2x weekly resistance training

Lifestyle

  • weight management toward healthy BMI Moderate

    Excess weight increases insulin resistance and T2D risk; weight loss improves metabolic function

    Achieve BMI 18.5-24.9 or lose 5-10% of body weight if overweight

Screening

  • type 2 diabetes screening Moderate

    rs12453376-G association with T2D at genome-wide significance suggests increased disease susceptibility

    Annual HbA1c and fasting glucose testing; earlier screening if family history present