Expressive

rs12453233 - EFCAB13-DT, EFCAB13

Magnitude 2.8 · 1 study on file

Reported associations

  • Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease - Unknown journal (n.d.) · Unknown authors · PubMed 35884923

    ABSTRACT: A comprehensive understanding of gene-diet interactions is necessary to establish proper dietary guidelines to prevent and manage cardio-cerebrovascular disease (CCD). We investigated the role of genetic variants associated with dyslipidaemia (DL) and their interactions with macro-nutrients for cardiovascular disease using a large-scale genome-wide association study of Korean adults. A total of 58,701 participants from a Korean genome and epidemiology study were included. Their dietary intake was assessed using a food frequency questionnaire. Dyslipidaemia was defined as total cholesterol (TCHL) ≥ 240 mg/dL, high-density lipoprotein (HDL) < 40 mg/dL, low-density lipoprotein (LDL) ≥ 160 mg/dL, triglycerides (TG) ≥ 200 mg/dL, or dyslipidaemia history. Their nutrient intake wa

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • reduce saturated fat, increase soluble fiber intake Moderate

    Genetic predisposition to higher cholesterol may be partially offset by dietary modifications that reduce cholesterol synthesis and increase excretion

    Target <7% calories from saturated fat (about 16g for 2000 kcal diet); 25-30g fiber daily

Exercise

  • regular aerobic exercise Moderate

    Exercise is known to improve lipid profiles and may partially offset genetic predisposition

    150 minutes moderate-intensity aerobic activity per week

Screening

  • lipid panel (total cholesterol, LDL, HDL, triglycerides) Moderate

    rs12453233 T allele carriers show elevated total cholesterol in GWAS of 58,701 participants; proactive monitoring enables early intervention

    Every 4-5 years starting at age 20; annually if results are elevated