Expressive

rs12453139 - PEMT - SMCR2

Magnitude 2.2 · 1 study on file

Reported associations

  • GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer - Unknown journal (n.d.) · Unknown authors · PubMed 34021172

    ABSTRACT: Genetic studies have examined body-shape measures adjusted for body mass index (BMI), while allometric indices are additionally adjusted for height. We performed the first genome-wide association study of A Body Shape Index (ABSI), Hip Index (HI) and the new Waist-to-Hip Index and compared these with traditional indices, using data from the UK Biobank Resource for 219,872 women and 186,825 men with white British ancestry and Bayesian linear mixed-models (BOLT-LMM). One to two thirds of the loci identified for allometric body-shape indices were novel. Most prominent was rs72959041 variant in RSPO3 gene, expressed in visceral adipose tissue and regulating adrenal cell renewal. Highly ranked were genes related to morphogenesis and organogenesis, previously additionally linked to can

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • regular aerobic and resistance training Moderate

    Visceral adiposity indicated by higher waist-hip ratio responds to both aerobic and resistance exercise

    Aim for 150 minutes aerobic activity and 2-3 weekly resistance training sessions

Lifestyle

  • weight management and body composition maintenance Moderate

    Central adiposity reflected in waist-hip ratio associates with metabolic and cardiovascular risk; weight stability or loss reduces visceral adiposity

    Maintain stable weight; if overweight, aim for 0.5-1 lb per week loss

Screening

  • waist-hip ratio and body composition Moderate

    rs12453139 G allele associates with higher waist-hip index, a marker of visceral adiposity and metabolic dysfunction

    Measure waist and hip circumference annually; calculate ratio (waist/hip); track trends