Expressive

rs12452324 - SHISA6

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome-wide association study for lung cancer in 6531 African Americans reveals new susceptibility loci. - Human molecular genetics (2025) · Byun J, Han Y, Choi J, Sun R, Shaw VR, Zhu C, Xiao X, Lusk C, Badr H, Lee HS, Jang HJ, Li Y, Lim H, Long E, Liu Y, Kachuri L, Walsh KM, Wiencke JK, Albanes D, Lam S, Tardon A, Neuhouser ML, Barnett MJ, Chen C, Bojesen S, Brenner H, Landi MT, Johansson M, Risch A, Wichmann HE, Bickeböller H, Christiani DC, Rennert G, Arnold S, Field JK, Shete S, Le Marchand L, Liu G, Andrew AS, Zienolddiny S, Grankvist K, Johansson M, Caporaso N, Taylor F, Lazarus P, Schabath MB, Aldrich MC, Patel A, Lin X, Zanetti KA, Harris CC, Chanock S, McKay J, Schwartz AG, Hung RJ, Amos CI · PubMed 40341939

    Despite lung cancer affecting all races and ethnicities, disparities are observed in incidence and mortality rates among different ethnic groups in the United States. Non-Hispanic African Americans had a high incidence rate of lung cancer at 55.8 per 100 000 people, as well as the highest death rate at 37.2 per 100 000 people from 2016 to 2020. While previous genome-wide association studies (GWAS) have identified over 45 susceptibility risk loci that influence lung cancer development, few GWAS have investigated the etiology of lung cancer in African Americans. To address this gap in knowledge, we conducted GWAS of lung cancer focused on studying African Americans, comprising 2267 lung cancer cases and 4264 controls. We identified three loci associated with lung cancer, one with lung ad

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • risk-stratified lung cancer screening strategy Moderate

    SHISA6 rs12452324 A allele carriers have significantly elevated squamous cell lung carcinoma risk that may warrant earlier or more frequent screening than standard guidelines.

Lifestyle

  • tobacco smoke Moderate

    SHISA6 rs12452324 A allele increases squamous cell lung carcinoma risk; smoking is a primary modifiable risk factor for this histological subtype.

    Smoking cessation if currently smoking; avoid secondhand smoke exposure.

Screening

  • lung cancer screening Moderate

    Carriers of SHISA6 rs12452324 risk allele A show 1.595-fold increased risk for squamous cell lung carcinoma in large GWAS.

    Discuss with physician about low-dose CT screening; consider starting at age 40-50 depending on individual risk.