rs12450778 - SRCIN1 - EPOP

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities - Unknown journal (n.d.) · Unknown authors · PubMed 30636644

  ABSTRACT: Background Alzheimer's disease (AD) is the most common cause of dementia in the elderly and the sixth leading cause of death in the United States. AD is mainly considered a complex disorder with polygenic inheritance. Despite discovering many susceptibility loci, a major proportion of AD genetic variance remains to be explained. Methods We investigated the genetic architecture of AD in four publicly available independent datasets through genome-wide association, transcriptome-wide association, and gene-based and pathway-based analyses. To explore differences in the genetic basis of AD between males and females, analyses were performed on three samples in each dataset: males and females combined, only males, or only females. Results Our genome-wide association analyses corrobora

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