rs12450368 - COX10 - CDRT15
Magnitude 2.2 · 2 studies on file
Reported associations
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Association of Myopia and Intraocular Pressure With Retinal Detachment in European Descent Participants of the UK Biobank Cohort: A Mendelian Randomization Study. - JAMA ophthalmology (2021) · Han X, Ong JS, An J, Craig JE, Gharahkhani P, Hewitt AW, MacGregor S · PubMed 32352494
Rhegmatogenous retinal detachment is a potentially sight-threatening condition. The role of myopia or intraocular pressure (IOP) in retinal detachment remains unclear. To determine if myopia or IOP is associated with retinal detachment risk using genetic data. Observational analyses and 2-sample mendelian randomization were used to evaluate the associations between myopia, IOP, and retinal detachment risk in European descent participants from the UK Biobank (UKBB) cohort (n = 405 692). For retinal detachment, a genome-wide association study on 4257 cases and 39 181 controls in the UKBB was conducted. Genetic variants associated with mean spherical equivalent (MSE) refractive error (n = 95 827) and IOP (n = 101 939) were derived using independent participants from the re
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Education interacts with genetic variants near GJD2, RBFOX1, LAMA2, KCNQ5 and LRRC4C to confer susceptibility to myopia - Unknown journal (n.d.) · Unknown authors · PubMed 36395078
ABSTRACT: Myopia most often develops during school age, with the highest incidence in countries with intensive education systems. Interactions between genetic variants and educational exposure are hypothesized to confer susceptibility to myopia, but few such interactions have been identified. Here, we aimed to identify genetic variants that interact with education level to confer susceptibility to myopia. Two groups of unrelated participants of European ancestry from UK Biobank were studied. A 'Stage-I' sample of 88,334 participants whose refractive error (avMSE) was measured by autorefraction and a 'Stage-II' sample of 252,838 participants who self-reported their age-of-onset of spectacle wear (AOSW) but who did not undergo autorefraction. Genetic variants were prioritized via a 2
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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outdoor time Moderate
Insufficient time outdoors is an established risk factor for myopia; outdoor light exposure helps regulate eye growth.
Aim for 1-2 hours daily, especially during school-age years
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prolonged unbroken near work Moderate
Excessive near work and accommodation stress are associated with myopia development, compounded by genetic predisposition at this locus.
Take 20-30 second breaks every 20 minutes; maintain minimum 30cm reading distance
Screening
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refractive error and myopia development Moderate
This variant is strongly associated with refractive error; early detection enables preventive and corrective interventions.
Annual eye exams; increase frequency during school years if myopia emerges