rs1244983 - CENPF - GAPDHP24

Magnitude 2.2 · 1 study on file

Reported associations

• Association between birth weight and refractive error in adulthood: a Mendelian randomisation study. - The British journal of ophthalmology (2020) · Plotnikov D, Williams C, Guggenheim JA · PubMed 31097437

  Pathological myopia is one of the leading causes of blindness globally. Lower birth weight (BW) within the normal range has been reported to increase the risk of myopia, although findings conflict. We sought to estimate the causal effect of BW on refractive error using Mendelian randomisation (MR), under the assumption of a linear relationship. Genetic variants associated with BW were identified from meta-analysis of a genome-wide association study (GWAS) for self-reported BW in 162 039 UK Biobank participants and a published Early Growth Genetics (EGG) consortium GWAS (n=26 836). We performed a one-sample MR analysis in 39 658 unrelated, adult UK Biobank participants (independent of the GWAS sample) using an allele score for BW as instrumental variable. A two-sample MR sensitivity a

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