rs12444565 - RBFOX1

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association study identifies locus influencing brain glucose metabolism. - Annals of translational medicine (2023) · Kong LL, Miao D, Tan L, Liu SL, Li JQ, Cao XP, Tan L · PubMed 30596066

  Fluorodeoxyglucose f18 positron emission tomography (18F-FDG PET) is regarded as the only functional neuroimaging biomarker for degeneration which can be used to increase the certainty of Alzheimer's disease (AD) pathophysiological process in research settings or as an optional clinical tool where available. Although a decline in FDG metabolism was confirmed in some regions known to be associated with AD, there was little known about the genetic association of FDG metabolism in AD cohorts. In this study, we present the first genome-wide association study (GWAS) analysis of brain FDG metabolism. A total of 222 individuals were included from the Alzheimer's Disease Neuroimaging Initiative 1 (ADNI-1) cohort. All subjects were restricted to non-Hispanic Caucasians and met all quality control (

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