rs12444195 - MTND5P34 - RN7SL841P

Magnitude 4.5 · 1 study on file

Reported associations

• Novel Genetic Determinants of Dental Maturation in Children. - Journal of dental research (2023) · Grgic O, Prijatelj V, Dudakovic A, Vucic S, Dhamo B, Trajanoska K, Monnereau C, Zrimsek M, Gautvik KM, Reppe S, Shimizu E, Haworth S, Timpson NJ, Jaddoe VWV, Jarvelin MR, Evans D, Uitterlinden AG, Ongkosuwito EM, van Wijnen AJ, Medina-Gomez C, Rivadeneira F, Wolvius EB · PubMed 36437532

  Dental occlusion requires harmonious development of teeth, jaws, and other elements of the craniofacial complex, which are regulated by environmental and genetic factors. We performed the first genome-wide association study (GWAS) on dental development (DD) using the Demirjian radiographic method. Radiographic assessments from participants of the Generation R Study (primary study population, = 2,793; mean age of 9.8 y) were correlated with ~30 million genetic variants while adjusting for age, sex, and genomic principal components (proxy for population stratification). Variants associated with DD at genome-wide significant level ( < 5 × 10 ) mapped to 16q12.2 ( ) (lead variant rs3922616, = 0.16; = 2.2 × 10 ). We used Fisher's combined probability tests weighted by samp

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