Expressive

rs12442060 - DAPK2

Magnitude 4.5 · 1 study on file

Reported associations

  • Identifying Blood Pressure Loci Whose Effects Are Modulated by Multiple Lifestyle Exposures - Unknown journal (n.d.) · Unknown authors · PubMed 32227373

    ABSTRACT: Although multiple lifestyle exposures simultaneously impact blood pressure (BP) and cardiovascular health, most analysis so far has considered each single lifestyle exposure (e.g., smoking) at a time. Here, we exploit gene-multiple lifestyle exposure interactions to find novel BP loci. For each of 6,254 Framingham Heart Study participants, we computed lifestyle risk score (LRS) value by aggregating the risk of four lifestyle exposures (smoking, alcohol, education, and physical activity) on BP. Using the LRS, we performed genome-wide gene-environment interaction analysis in systolic and diastolic BP using the joint 2 degree of freedom (DF) and 1 DF interaction tests. We identified one genome-wide significant (P-value < 5 × 10−8) and 11 suggestive (P-value < 1 × 10−6) loci. G

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • moderate alcohol consumption Moderate

    Alcohol intake is a component of lifestyle burden score; moderate consumption (not abstinence or heavy drinking) is associated with favorable profile in rs12442060-BP interaction.

    Limit alcohol to 1-7 drinks per week

Exercise

  • regular physical activity Moderate

    DAPK2 variants show gene-lifestyle interaction; maintaining physical activity is part of favorable lifestyle profile that modulates rs12442060 effects on blood pressure.

    Aim for 150 minutes of moderate aerobic activity weekly

Lifestyle

  • smoking Moderate

    Smoking status is a key component of lifestyle burden in the rs12442060-BP interaction; avoiding smoking reduces overall lifestyle risk score that modulates genetic effects.

    Quit if currently smoking; maintain smoking cessation

Screening

  • systolic blood pressure Moderate

    rs12442060 is associated with systolic BP through gene-lifestyle interaction; DAPK2 mediates mTOR signaling affecting vascular function and BP regulation.

    Monitor at regular clinical visits; home monitoring if readings are elevated