rs12440952 - CCDC33

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic analyses identify widespread sex-differential participation bias - Unknown journal (n.d.) · Unknown authors · PubMed 33888908

  ABSTRACT: Genetic association results are often interpreted with the assumption that study participation does not affect downstream analyses. Understanding the genetic basis of participation bias is challenging as it requires genotypes of unseen individuals. Here we demonstrate that it is possible to estimate comparative biases by performing a genome-wide association study (GWAS) contrasting one subgroup versus another. For example, we show that sex exhibits artefactual autosomal heritability in the presence of sex-differential participation bias. By performing a GWAS of sex in ∼3.3 million males and females, we identify over 158 autosomal loci spuriously associated with sex and highlight complex traits underpinning differences in study participation between sexes. For example, the body

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.