rs12440564 - GOLGA8B - LINC02252

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders. - Annals of translational medicine (2024) · Niu LD, Xu W, Li JQ, Tan CC, Cao XP, Yu J, Tan L · PubMed 31930058

  Cerebrospinal fluid (CSF) neurofilament light (NFL) is a general biomarker for axonal damage. This genome-wide association study (GWAS) consisted of 169 mild cognitive impairment (MCI) subjects and 94 cognitively normal (CN) subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Analyses of associations between CSF NFL and genetic polymorphisms were performed using an additive genetic model. The novel single nucleotide polymorphisms (SNPs) identified by GWAS were further examined for their correlation with other AD-related phenotypes at baseline and during follow-up using multiple linear regression model and mixed effects model respectively. Survival analysis was performed to evaluate the respective risks of progression from CN to prodromal AD and from MCI to AD among

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