rs12439944 - CSK
Magnitude 2.8 · 1 study on file
Reported associations
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Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes - Unknown journal (n.d.) · Unknown authors · PubMed 28604730
ABSTRACT: Summary While several lung cancer susceptibility loci have been identified, much of lung cancer heritability remains unexplained. Here, 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated GWAS analysis of lung cancer on 29,266 patients and 56,450 controls. We identified 18 susceptibility loci achieving genome wide significance, including 10 novel loci. The novel loci highlighted the striking heterogeneity in genetic susceptibility across lung cancer histological subtypes, with four loci associated with lung cancer overall and six with lung adenocarcinoma. Gene expression quantitative trait analysis (eQTL) in 1,425 normal lung tissues highlighted RNASET2, SECISBP2L and NRG1 as candidate genes. Other
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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cigarette smoking Moderate
CSK rs12439944 T allele increases lung cancer risk in smokers by approximately 21 percent, suggesting impaired protective mechanisms
if currently smoking, discuss cessation with healthcare provider; consider evidence-based cessation programs
Screening
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lung cancer screening eligibility assessment Moderate
CSK T allele carriers with smoking history or exposure have elevated lung cancer risk warranting clinical risk assessment
discuss with healthcare provider about screening timing, eligibility, and personal or family cancer history